The Bicarbonate Transporter Is Essential for Bacillus anthracis Lethality

@article{Wilson2008TheBT,
  title={The Bicarbonate Transporter Is Essential for Bacillus anthracis Lethality},
  author={Adam C. Wilson and Magali Soyer and James A. Hoch and Marta Perego},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={815 - 826}
}
In the pathogenic bacterium Bacillus anthracis, virulence requires induced expression of the anthrax toxin and capsule genes. Elevated CO2/bicarbonate levels, an indicator of the host environment, provide a signal ex vivo to increase expression of virulence factors, but the mechanism underlying induction and its relevance in vivo are unknown. We identified… CONTINUE READING