The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus

  title={The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus},
  author={C. Brooke. Steele and Rekha R. Rapaka and Allison E. Metz and Shannon M Pop and David M. L. Williams and Siamon Gordon and Jay K Kolls and Gordon D Brown},
  journal={PLoS Pathogens},
  pages={161 - 172}
Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage recognition receptor is critical for innate immunity to A. fumigatus. Acknowledging that the A. fumigatus cell wall contains a high beta-1,3-glucan content, we questioned whether the beta-glucan receptor dectin-1 played a role in this recognition process. Monoclonal antibody, soluble receptor, and… CONTINUE READING
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Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxygen intermediates

  • B Philippe, O Ibrahim-Granet, MC Prevost, MA Gougerot Pocidalo, MS Perez
  • Infect Immun
  • 2003
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