The Benzyne Story

  title={The Benzyne Story},
  author={C. Wentrup},
  journal={Australian Journal of Chemistry},
  • C. Wentrup
  • Published 2010
  • Chemistry
  • Australian Journal of Chemistry
The history of o-benzyne from its early beginnings as an unobservable reactive intermediate until its present status as a very well characterized but still theoretically challenging molecule with important applications in synthesis is reviewed. The m- and p-benzynes, tridehydrobenzenes, and benzdiynes are also known, and p-benzyne is a key intermediate in the action of a potent class of ene-diyne anti-tumour compounds. 

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