The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond.

  title={The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond.},
  author={Sarah F. Funderburk and Qing Wang and Zhenyu Yue},
  journal={Trends in cell biology},
  volume={20 6},
An increasing body of research on autophagy provides overwhelming evidence for its connection to diverse biological functions and human diseases. Beclin 1, the first mammalian autophagy protein to be described, appears to act as a nexus point between autophagy, endosomal, and perhaps also cell death pathways. Beclin 1 performs these roles as part of a core complex that contains vacuolar sorting protein 34 (VPS34), a class III phosphatidylinositol-3 kinase. The precise mechanism of Beclin 1… CONTINUE READING
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