The Bcl2 family: regulators of the cellular life-or-death switch

@article{Cory2002TheBF,
  title={The Bcl2 family: regulators of the cellular life-or-death switch},
  author={Suzanne Cory and Kevin J. Duffy},
  journal={Nature Reviews Cancer},
  year={2002},
  volume={2},
  pages={647-656}
}
Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed by proteases called caspases. The Bcl2 family of intracellular proteins is the central regulator of caspase activation, and its opposing factions of anti- and pro-apoptotic members arbitrate the life-or-death decision. Apoptosis is often impaired in cancer and can limit conventional therapy. A better understanding of how the Bcl2 family controls caspase activation should result in new, more effective… CONTINUE READING
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