The Bcl2 family: regulators of the cellular life-or-death switch

@article{Cory2002TheBF,
  title={The Bcl2 family: regulators of the cellular life-or-death switch},
  author={Suzanne Cory and Jerry Adams},
  journal={Nature Reviews Cancer},
  year={2002},
  volume={2},
  pages={647-656}
}
Key Points Apoptosis, the cell-death programme that is mediated by proteases called caspases, is essential for tissue homeostasis, and its perturbed regulation underlies many diseases, including cancer. Commitment to apoptosis in response to diverse physiological cues and cytotoxic agents is governed by proteins of the Bcl2 family. Bcl2 and several pro-survival relatives associate with the mitochondrial outer membrane and the endoplasmic reticulum/nuclear membrane and maintain their integrity… CONTINUE READING
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