The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells

@inproceedings{Pont2014TheBI,
  title={The Bcl-2 inhibitor Obatoclax overcomes resistance to histone deacetylase inhibitors SAHA and LBH589 as radiosensitizers in patient-derived glioblastoma stem-like cells},
  author={Lotte M.E. Berghauser Pont and Jochem K. H. Spoor and Subramanian Venkatesan and Sigrid M. A. Swagemakers and Jenneke J. Kloezeman and Clemens M. F. Dirven and Peter J. van der Spek and Martine L. M. Lamfers and S. Leenstra},
  booktitle={Genes & cancer},
  year={2014}
}
Glioblastoma has shown resistance to histone deacetylase inhibitors (HDACi) as radiosensitizers in cultures with Bcl-XL over-expression. We study the efficacy of SAHA/RTx and LBH589/RTx when manipulating Bcl-2 family proteins using the Bcl-2 inhibitor Obatoclax in patient-derived glioblastoma stem-like cell (GSC) cultures. GSC cultures in general have a deletion in phosphatase and tensin homolog (PTEN). Synergy was determined by the Chou Talalay method. The effects on apoptosis and autophagy… CONTINUE READING
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