The Bcl-2 homology domain 3 (BH3) mimetic ABT-737 reveals the dynamic regulation of bad, a proapoptotic protein of the Bcl-2 family, by Bcl-xL.

@article{Ezzoukhry2011TheBH,
  title={The Bcl-2 homology domain 3 (BH3) mimetic ABT-737 reveals the dynamic regulation of bad, a proapoptotic protein of the Bcl-2 family, by Bcl-xL.},
  author={Zakaria Ezzoukhry and Christophe Louandre and Catherine François and Zuzana Saidak and Corinne Godin and J. C. Mazi{\`e}re and Antoine Galmiche},
  journal={Molecular pharmacology},
  year={2011},
  volume={79 6},
  pages={997-1004}
}
The proteins of the B-cell lymphoma 2 (Bcl-2) family are important regulators of apoptosis under normal and pathological conditions. Chemical compounds that block the antiapoptotic proteins of this family have been introduced, such as 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide (ABT-737), a BH3-mimetic that neutralizes Bcl-2 and Bcl-xL. In this study, we used ABT-737 to explore… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Structural insights into the degradation of Mcl - 1 induced by BH 3 domains

  • PE Czabotar, EF Lee, +6 authors PM Colman
  • Proc Natl Acad Sci USA
  • 2007
Highly Influential
11 Excerpts

Similar Papers

Loading similar papers…