The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice

@inproceedings{Harder2012TheBF,
  title={The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice},
  author={Jeffrey M Harder and Kimberly A. Fernandes and Richard T Libby},
  booktitle={Scientific reports},
  year={2012}
}
Axonal insult induces retinal ganglion cell (RGC) death through a BAX-dependent process. The pro-apoptotic Bcl-2 family member BIM is known to induce BAX activation. BIM expression increased in RGCs after axonal injury and its induction was dependent on JUN. Partial and complete Bim deficiency delayed RGC death after mechanical optic nerve injury. However, in a mouse model of glaucoma, DBA/2J mice, Bim deficiency did not prevent RGC death in eyes with severe optic nerve degeneration. In a… CONTINUE READING