The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis.

@article{Raisova2001TheBR,
  title={The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis.},
  author={Monika Raisova and Amir M. Hossini and J{\"u}rgen Eberle and Christian Riebeling and Thomas Wieder and Isrid Sturm and Peter T. Daniel and Constantin E. Orfanos and Christoph C. Geilen},
  journal={The Journal of investigative dermatology},
  year={2001},
  volume={117 2},
  pages={
          333-40
        }
}
Defective cytochrome c release and the resulting loss of caspase-3 activation was recently shown to be essential for the susceptibility of human melanoma cells to CD95/Fas-induced apoptosis. Cytochrome c release from mitochondria is regulated by the relative amounts of apoptosis-promoting and apoptosis-inhibiting Bcl-2 proteins in the outer membrane of these organelles. The assignment of Bax/Bcl-2 ratios by quantitative Western blotting in 11 melanoma cell populations revealed a relation to the… 

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