The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death.

@article{Galindo2009TheBO,
  title={The Bax/Bak ortholog in Drosophila, Debcl, exerts limited control over programmed cell death.},
  author={Kathleen A. Galindo and Wan-Jin Lu and Jae H Park and John M. Abrams},
  journal={Development},
  year={2009},
  volume={136 2},
  pages={275-83}
}
Bcl-2 family members are pivotal regulators of programmed cell death (PCD). In mammals, pro-apoptotic Bcl-2 family members initiate early apoptotic signals by causing the release of cytochrome c from the mitochondria, a step necessary for the initiation of the caspase cascade. Worms and flies do not show a requirement for cytochrome c during apoptosis, but both model systems express pro- and anti-apoptotic Bcl-2 family members. Drosophila encodes two Bcl-2 family members, Debcl (pro-apoptotic… CONTINUE READING

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