The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State With Reduced Tumorigenic Potential

@inproceedings{Kim2015TheBH,
  title={The Basic Helix-Loop-Helix Transcription Factor E47 Reprograms Human Pancreatic Cancer Cells to a Quiescent Acinar State With Reduced Tumorigenic Potential},
  author={Sangwun Kim and Reyhaneh Lahmy and Chelsea Riha and Challeng Yang and Brad L. Jakubison and Jaco van Niekerk and Claudio Staub and Yifan Wu and Keith P. Gates and Duc Si Dong and Stephen F Konieczny and Pamela Itkin-Ansari},
  booktitle={Pancreas},
  year={2015}
}
OBJECTIVES Pancreatic ductal adenocarcinoma (PDA) initiates from quiescent acinar cells that attain a Kras mutation, lose signaling from basic helix-loop-helix (bHLH) transcription factors, undergo acinar-ductal metaplasia, and rapidly acquire increased growth potential. We queried whether PDA cells can be reprogrammed to revert to their original quiescent acinar cell state by shifting key transcription programs. METHODS Human PDA cell lines were engineered to express an inducible form of the… CONTINUE READING

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