The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche

  title={The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche},
  author={Hironobu Fujiwara and Manuela Ferreira and Giacomo Donati and Denise K Marciano and James M. Linton and Yuya Sato and Andrea Hartner and Kiyotoshi Sekiguchi and Louis French Reichardt and Fiona M Watt},
The hair follicle bulge in the epidermis associates with the arrector pili muscle (APM) that is responsible for piloerection ("goosebumps"). We show that stem cells in the bulge deposit nephronectin into the underlying basement membrane, thus regulating the adhesion of mesenchymal cells expressing the nephronectin receptor, α8β1 integrin, to the bulge. Nephronectin induces α8 integrin-positive mesenchymal cells to upregulate smooth muscle markers. In nephronectin knockout mice, fewer arrector… CONTINUE READING


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