The Balance between Plasmacytoid DC versus Conventional DC Determines Pulmonary Immunity to Virus Infections

@article{Smit2008TheBB,
  title={The Balance between Plasmacytoid DC versus Conventional DC Determines Pulmonary Immunity to Virus Infections},
  author={Joost J. Smit and Dennis M. Lindell and Louis Boon and Mirjam Kool and Bart M. Lambrecht and Nicholas W Lukacs},
  journal={PLoS ONE},
  year={2008},
  volume={3}
}
BACKGROUND Respiratory syncytial virus (RSV) infects nearly all infants by age 2 and is a leading cause of bronchiolitis. RSV may employ several mechanisms to induce immune dysregulation, including dendritic cell (DC) modulation during the immune response to RSV. METHODS AND FINDINGS Expansion of cDC and pDC by Flt3L treatment promoted an anti-viral response with reduced pathophysiology characterized by decreased airway hyperreactivity, reduced Th2 cytokines, increased Th1 cytokines, and a… CONTINUE READING
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Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen

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