The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors.

@article{Marisa2018TheBB,
  title={The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors.},
  author={Laetitia Marisa and Magali Svrcek and Ada Collura and Etienne Becht and Pascale Cervera and Kristell Wanherdrick and Olivier Buhard and Anastasia R. Goloudina and Vincent Jonch{\`e}re and Janick S{\`e}lves and G{\'e}rard Milano and Dominique Gu{\'e}not and Romain Cohen and Chrystelle Colas and Pierre Laurent-Puig and Sylviane Olschwang and Jeremie H Lefevre and Yann R Parc and Val{\'e}rie Boige and C{\^o}me Lepage and Thierry Andr{\'e} and J. -F. Flejou and Valentin D{\'e}rang{\`e}re and François Ghiringhelli and Aur{\'e}lien de Reyni{\'e}s and A Duval},
  journal={Journal of the National Cancer Institute},
  year={2018},
  volume={110 1}
}
Background Immune checkpoint (ICK) expression might represent a surrogate measure of tumor-infiltrating T cell (CTL) exhaustion and therefore be a more accurate prognostic biomarker for colorectal cancer (CRC) patients than CTL enumeration as measured by the Immunoscore. Methods The expression of ICKs, Th1, CTLs, cytotoxicity-related genes, and metagenes, including Immunoscore-like metagenes, were evaluated in three independent cohorts of CRC samples (260 microsatellite instable [MSI], 971… CONTINUE READING