The Bakerian Lecture - Towards synthesis of proteins

@article{Kenner1977TheBL,
  title={The Bakerian Lecture - Towards synthesis of proteins},
  author={George W. Kenner},
  journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
  year={1977},
  volume={197},
  pages={237 - 253}
}
  • G. Kenner
  • Published 15 June 1977
  • Chemistry
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
Proteins, as their name indicates, occupy the prime place in Nature’s architecture. It is worth remarking that Nature uses the structural type for diverse purposes, in addition to those familiar in enzymology, immunology, etc. A striking example is provided by the recent publication (Bradbury et al. 1976), showing that the C fragment of lipotropin (residues 61‒91) is firmly bound by opiate receptors and is an analgesic 200 times as potent as morphine in molar terms. The pentapeptide comprising… 
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References

SHOWING 1-8 OF 8 REFERENCES
The constitution and properties of two gastrins extracted from hog antral mucosa
This paper is the culmination of many years' work on the detection, isolation, physiological study, and now, large-scale production of gastrin. The final product has been identified as two almost
Primary structure of lysozymes from man and goose.
The primary structure of goose egg white lysozyme seems to be distinct from that of hen egg white and human leukaemia lysozymes.