The Bacteroides fragilis transcriptome response to oxygen and H2O2: the role of OxyR and its effect on survival and virulence.

@article{Sund2008TheBF,
  title={The Bacteroides fragilis transcriptome response to oxygen and H2O2: the role of OxyR and its effect on survival and virulence.},
  author={Christian J. Sund and Edson R Rocha and Arthur O. Tzianabos and Wade G. Wells and Jason M Gee and Michael A Reott and Dorcas P O'Rourke and C Jeffrey Smith},
  journal={Molecular microbiology},
  year={2008},
  volume={67 1},
  pages={129-42}
}
The intestinal anaerobic symbiont, Bacteroides fragilis, is highly aerotolerant and resistant to H(2)O(2). Analysis of the transcriptome showed that expression of 45% of the genome was significantly affected by oxidative stress. The gene expression patterns suggested that exposure to oxidative stress induced an acute response to rapidly minimize the immediate effects of reactive oxygen species, then upon extended exposure a broad metabolic response was induced. This metabolic response induced… CONTINUE READING

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