The Bacterial Effector VopL Organizes Actin into Filament-like Structures

  title={The Bacterial Effector VopL Organizes Actin into Filament-like Structures},
  author={Jacob A. Zahm and Shae B. Padrick and Zhucheng Chen and Chi W. Pak and Ali A. Yunus and Lisa M Henry and Diana R Tomchick and Zhe Chen and Michael K Rosen},
VopL is an effector protein from Vibrio parahaemolyticus that nucleates actin filaments. VopL consists of a VopL C-terminal domain (VCD) and an array of three WASP homology 2 (WH2) motifs. Here, we report the crystal structure of the VCD dimer bound to actin. The VCD organizes three actin monomers in a spatial arrangement close to that found in the canonical actin filament. In this arrangement, WH2 motifs can be modeled into the binding site of each actin without steric clashes. The data… CONTINUE READING
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