The Bacillus subtilis sin operon: an evolvable network motif.

  title={The Bacillus subtilis sin operon: an evolvable network motif.},
  author={Christopher A. Voigt and Denise M. Wolf and Adam Paul Arkin},
  volume={169 3},
The strategy of combining genes from a regulatory protein and its antagonist within the same operon, but controlling their activities differentially, can lead to diverse regulatory functions. This protein-antagonist motif is ubiquitous and present in evolutionarily unrelated regulatory pathways. Using the sin operon from the Bacillus subtilis sporulation pathway as a model system, we built a theoretical model, parameterized it using data from the literature, and used bifurcation analyses to… CONTINUE READING
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