The Bacillus anthracis cholesterol-dependent cytolysin, Anthrolysin O, kills human neutrophils, monocytes and macrophages

@article{Mosser2006TheBA,
  title={The Bacillus anthracis cholesterol-dependent cytolysin, Anthrolysin O, kills human neutrophils, monocytes and macrophages},
  author={Elise M. Mosser and Richard F. Rest},
  journal={BMC Microbiology},
  year={2006},
  volume={6},
  pages={56 - 56}
}
BackgroundBacillus anthracis is an animal and human pathogen whose virulence is characterized by lethal and edema toxin, as well as a poly-glutamic acid capsule. In addition to these well characterized toxins, B. anthracis secretes several proteases and phospholipases, and a newly described toxin of the cholesterol-dependent cytolysin (CDC) family, Anthrolysin O (ALO).ResultsIn the present studies we show that recombinant ALO (rALO) or native ALO, secreted by viable B. anthracis, is lethal to… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 23 CITATIONS

Activation of the latent PlcR regulon in Bacillus anthracis

  • Microbiology
  • 2010
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Bacterial Virulence Factors: Secreted for Survival

  • Indian Journal of Microbiology
  • 2016
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Cholesterol and the activity of bacterial toxins.

  • FEMS microbiology letters
  • 2004
VIEW 1 EXCERPT