The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse.

@article{Tailor2008TheBM,
  title={The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse.},
  author={Prafullakumar Tailor and Tomohiko Tamura and Herbert C. Morse and Keiko Ozato},
  journal={Blood},
  year={2008},
  volume={111 4},
  pages={1942-5}
}
Among dendritic cell (DC) subsets, CD8alpha(+) DCs and plasmacytoid DCs (pDCs) produce high levels of IL12 and type I interferons (IFNs), respectively, and confer early innate immunity. Development of CD8alpha(+) DCs and pDCs requires the interferon regulatory factor 8 (IRF8). Recently, a spontaneous point mutation was identified in the Irf8/Icsbp gene in the BXH2 mouse, which exhibits an immunodeficient phenotype similar to the IRF8 knockout (KO) mouse. We show that this mutation, designated… CONTINUE READING

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