The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.

@article{Chu2006TheBC,
  title={The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.},
  author={Yaya Chu and Ann Sutton and Rolf Sternglanz and Gregory Prelich},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 8},
  pages={3029-38}
}
BUR1 and BUR2 encode the catalytic and regulatory subunits of a cyclin-dependent protein kinase complex that is essential for normal growth and has a general role in transcription elongation. To gain insight into its specific role in vivo, we identified mutations that reverse the severe growth defect of bur1Delta cells. This selection identified mutations in SET2, which encodes a histone methylase that targets lysine 36 of histone H3 and, like BUR1, has a poorly characterized role during… CONTINUE READING
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