The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity

@inproceedings{Chevrier2014TheBT,
  title={The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity},
  author={St{\'e}phane Chevrier and Dianne Emslie and Wei Shi and Tobias Kratina and Cameron J. Wellard and Alexander Karnowski and Erdem Erikci and Gordon K Smyth and K. Chowdhury and David M Tarlinton and Lynn M Corcoran},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
The transcriptional network regulating antibody-secreting cell (ASC) differentiation has been extensively studied, but our current understanding is limited. The mechanisms of action of known "master" regulators are still unclear, while the participation of new factors is being revealed. Here, we identify Zbtb20, a Bcl6 homologue, as a novel regulator of late B cell development. Within the B cell lineage, Zbtb20 is specifically expressed in B1 and germinal center B cells and peaks in long-lived… CONTINUE READING
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