The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer

@inproceedings{Wu2017TheBA,
  title={The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a
driver of cancer},
  author={Qiong Wu and Jane B Lian and Janet L Stein and Gary S Stein and Jeffrey A. Nickerson and Anthony N Imbalzano},
  booktitle={Epigenomics},
  year={2017}
}
Mammalian SWI/SNF enzymes are ATP-dependent remodelers of chromatin structure. These multisubunit enzymes are heterogeneous in composition; there are two catalytic ATPase subunits, BRM and BRG1, that are mutually exclusive, and additional subunits are incorporated in a combinatorial manner. Recent findings indicate that approximately 20% of human cancers contain mutations in SWI/SNF enzyme subunits, leading to the conclusion that the enzyme subunits are critical tumor suppressors. However… CONTINUE READING
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