The BRCA2 transactivation domain does not interact with JNK.

@article{May1999TheBT,
  title={The BRCA2 transactivation domain does not interact with JNK.},
  author={Gerhard H W May and Frederick Harris and David Gillespie and Donald M. Black},
  journal={Genes, chromosomes & cancer},
  year={1999},
  volume={25 4},
  pages={407-9}
}
The N-terminal region of BRCA2 has the capacity to activate transcription when fused to a heterologous DNA binding domain and includes a segment with amino acid similarity to the JNK-docking site in the cellular JUN protein. However, unlike JUN, we have determined that this region of BRCA2 neither interacts with nor serves as a substrate for JNK, or any other kinase that can be detected in extracts from either fibroblasts or epithelial cells. While this clearly does not rule out a… CONTINUE READING