The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes.

  title={The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes.},
  author={Jeffrey D. Parvin},
  journal={Environmental and molecular mutagenesis},
  volume={50 8},
Mutation of the breast and ovarian cancer specific tumor suppressor, BRCA1, results in supernumerary and hyperactive centrosomes, which in turn likely contribute to the aneuploidy evident in breast cancer cells. The BRCA1-dependent ubiquitin ligase activity is required for the regulation of centrosome function, and among its substrates is gamma-tubulin. Data suggest that during S and G2 phases of the cell cycle, the normal function of BRCA1 directs the ubiquitination of gamma-tubulin, resulting… CONTINUE READING