The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.

  title={The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations.},
  author={Sharon B Cantor and Ronny Drapkin and Fan Zhang and Yafang Lin and Juliana Han and Sushmita Pamidi and David M. Livingston},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 8},
BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between BRCA1 and BACH1, lead to defects in DNA repair, and result in breast and ovarian cancer. BACH1 is necessary for efficient double-strand break repair in a manner that depends on its association with BRCA1. Moreover, some women with early-onset breast cancer and no abnormalities in either BRCA1 or… CONTINUE READING
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