The BRCA1 C-terminal domain: structure and function.

  title={The BRCA1 C-terminal domain: structure and function.},
  author={T Huyton and Paul A. Bates and Xian-En Zhang and Michael J. E. Sternberg and Paul S. Freemont},
  journal={Mutation research},
  volume={460 3-4},
The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and… CONTINUE READING