The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.

@article{Wang2016TheBA,
  title={The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin.},
  author={Yifan Wang and Andrea J. Bernhardy and Cristina Cruz and John J. Krais and Joseph Nacson and Emmanuelle E. Nicolas and Suraj Peri and Hanneke van der Gulden and Ingrid van der Heijden and Shane W. O'Brien and Yong Zhang and Maribel I. Harrell and Shawn F. Johnson and Francisco Jos{\'e} Candido dos Reis and Paul D P Pharoah and Beth Y. Karlan and Charlie Gourley and Diether Lambrechts and Georgia Chenevix-Trench and H{\aa}kan Olsson and Javier Ben{\'i}tez and Mark H Greene and MartinE. Gore and Robert L Nussbaum and Siegal Sadetzki and Simon A. Gayther and Susanne K Kjaer and Alan D' Andrea and Geoffrey I. Shapiro and David L Wiest and Denise C. Connolly and Mary B Daly and Elizabeth M. Swisher and Peter Bouwman and Jos Jonkers and Judith Balma{\~n}a and Violeta Serra and Neil W. Johnson},
  journal={Cancer research},
  year={2016},
  volume={76 9},
  pages={
          2778-90
        }
}
Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impact of mutations on BRCA1 isoform expression and therapeutic response. Cancer cell lines and tumors harboring mutations in exon 11 of BRCA1 express a BRCA1-Δ11q splice variant lacking the majority of exon 11. The introduction of frameshift mutations… CONTINUE READING
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A high-throughput functional complementation assay for classification of BRCA1 missense variants

  • P. Bouwman, H. van der Gulden, +8 authors F.B
  • Cancer Discov 3:1142-1155
  • 2013
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