The BRCA1/BARD1 Heterodimer Modulates Ran-Dependent Mitotic Spindle Assembly

@article{Joukov2006TheBH,
  title={The BRCA1/BARD1 Heterodimer Modulates Ran-Dependent Mitotic Spindle Assembly},
  author={V. Joukov and A. Groen and T. Prokhorova and Ruth Gerson and Erinn White and A. Rodr{\'i}guez and J. Walter and D. Livingston},
  journal={Cell},
  year={2006},
  volume={127},
  pages={539-552}
}
The heterodimeric tumor-suppressor complex BRCA1/BARD1 exhibits E3 ubiquitin ligase activity and participates in cell proliferation and chromosome stability control by incompletely defined mechanisms. Here we show that, in both mammalian cells and Xenopus egg extracts, BRCA1/BARD1 is required for mitotic spindle-pole assembly and for accumulation of TPX2, a major spindle organizer and Ran target, on spindle poles. This function is centrosome independent, operates downstream of Ran GTPase, and… Expand
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BRCA1 Interaction of Centrosomal Protein Nlp Is Required for Successful Mitotic Progression*♦
Regulated degradation of spindle assembly factors by the anaphase-promoting complex.
The MRN-CtIP pathway is required for metaphase chromosome alignment.
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References

SHOWING 1-10 OF 50 REFERENCES
Nucleophosmin/B23 Is a Candidate Substrate for the BRCA1-BARD1 Ubiquitin Ligase*
BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number.
Targeting of RCC1 to Chromosomes Is Required for Proper Mitotic Spindle Assembly in Human Cells
BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number
Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
XRHAMM Functions in Ran-Dependent Microtubule Nucleation and Pole Formation during Anastral Spindle Assembly
BRCA1 is associated with the centrosome during mitosis.
  • L. Hsu, R. White
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development
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3
4
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