The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2

@inproceedings{Gu2015TheBM,
  title={The BRCA1/2-directed miRNA signature predicts a good prognosis in ovarian cancer patients with wild-type BRCA1/2},
  author={Yunyan Gu and Mengmeng Zhang and Fuduan Peng and Lei Fang and Yuanyuan Zhang and Haihai Liang and Wenbin Zhou and Lu Ao and Zheng Guo},
  booktitle={Oncotarget},
  year={2015}
}
Ovarian cancer patients carrying alterations (i.e., germline mutations, somatic mutations, hypermethylations and/or deletions) of BRCA1 or BRCA2 (BRCA1/2) have a better prognosis than BRCA1/2 alteration non-carriers. However, patients with wild-type BRCA1/2 may also have a favorable prognosis as a result of other mechanisms that remain poorly elucidated, such as the deregulation of miRNAs. We therefore sought to identify BRCA1/2-directed miRNA signatures that have prognostic value in ovarian… CONTINUE READING
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