The BRAINS study: safety, tolerability, and dose-finding of repinotan in acute stroke.

@article{Teal2005TheBS,
  title={The BRAINS study: safety, tolerability, and dose-finding of repinotan in acute stroke.},
  author={Philip A. Teal and Frank L. Silver and Denis Simard},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  year={2005},
  volume={32 1},
  pages={61-7}
}
BACKGROUND AND PURPOSE Repinotan is a potent, serotonin (5-HT1A) full receptor agonist that interferes with ischemia-mediated neuronal cell death in animal models. This double-blind, placebo-controlled phase II study examined the safety, tolerability, and dose of repinotan in patients with acute ischemic stroke. METHODS Patients with acute hemispheric… CONTINUE READING