The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer.

@article{RiescoEizaguirre2009TheBO,
  title={The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer.},
  author={Garcilaso Riesco-Eizaguirre and Irene Mateos Rodr{\'i}guez and Antonio De la Vieja and Eugenia Costamagna and Nancy Carrasco and Manuel Nistal and Pilar Santisteban},
  journal={Cancer research},
  year={2009},
  volume={69 21},
  pages={8317-25}
}
The activating mutation BRAF(V600E) is a frequent genetic event in papillary thyroid carcinomas (PTC) that predicts a poor prognosis, leading to loss of sodium/iodide symporter (NIS) expression and subsequent radioiodide-refractory metastatic disease. The molecular basis of such an aggressive behavior induced by BRAF remains unclear. Here, we show a mechanism through which BRAF induces NIS repression and promotes epithelial to mesenchimal transition and invasion based on the operation of an… CONTINUE READING
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The oncogene BRAF V600E is associated with a high risk of recurrence and less differentiated papillary thyroid carcinoma due Cancer Research 8324

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Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling

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