The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cells.

@article{Hou2012TheBC,
  title={The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cells.},
  author={Peng Hou and Dingxie Liu and Jiangli Dong and Mingzhao Xing},
  journal={Cell cycle},
  year={2012},
  volume={11 2},
  pages={286-95}
}
Although BRAF(V600E) is well known to play an important role in the tumorigenesis of melanoma, its molecular mechanism, particularly the epigenetic aspect, has been incompletely understood. Here, we investigated the role of BRAF(V600E) signaling in altering gene methylation in the genome of melanoma cells using a methylated CpG island amplification/CpG island microarray system and searched for genes coupled to the BRAF(V600E) signaling through methylation aberrations. The results indicated that… CONTINUE READING

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