The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

@article{Thierry1987TheBT,
  title={The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.},
  author={Françoise Thierry and M. Yaniv},
  journal={The EMBO journal},
  year={1987},
  volume={6 11},
  pages={3391-7}
}
The human papillomavirus 18 (HPV 18) long control region contains promoter and enhancer elements whose activity is restricted to several human cell lines of epithelial origin. This enhancer possesses a considerable constitutive activity which is further stimulated in the presence of the E2 trans-activating protein of bovine papillomavirus 1 (BPV1). Surprisingly the same BPV1 protein strongly repressed transcription from the genuine HPV18 enhancer-promoter DNA sequences. We suggest that binding… CONTINUE READING

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