The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation

@article{Buijs2012TheBH,
  title={The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation},
  author={Jeroen T. Buijs and Geertje van der Horst and C van den Hoogen and H Cheung and B de Rooij and Jeffrey Kroon and Maj Petersen and Petra G. M. van Overveld and Rob C. M. Pelger and Gabri van der Pluijm},
  journal={Oncogene},
  year={2012},
  volume={31},
  pages={2164-2174}
}
Accumulating evidence suggests that a subpopulation of breast cancer cells, referred to as cancer stem cells (CSCs), have the ability to propagate a tumor and potentially seed new metastases. Furthermore, stimulation of an epithelial-to-mesenchymal transition by factors like transforming growth factor-β (TGFβ) is accompanied with the generation of breast CSCs. Previous observations indicated that bone morphogenetic protein-7 (BMP7) antagonizes the protumorigenic and prometastatic actions of TGF… CONTINUE READING