The BMP family member Gdf7 is required for seminal vesicle growth, branching morphogenesis, and cytodifferentiation.
@article{Settle2001TheBF, title={The BMP family member Gdf7 is required for seminal vesicle growth, branching morphogenesis, and cytodifferentiation.}, author={Stephen H. Settle and Paul C Marker and Kyle A. Gurley and Abhishek Sinha and Abigail Thacker and Y Z Wang and Kay M. Higgins and Gerald R. Cunha and David M. Kingsley}, journal={Developmental biology}, year={2001}, volume={234 1}, pages={ 138-50 } }
Epithelial-mesenchymal interactions play an important role in the development of many different organs and tissues. The secretory glands of the male reproductive system, including the prostate and seminal vesicles, are derived from epithelial precursors. Signals from the underlying mesenchyme are required for normal growth, branching, and differentiation of the seminal vesicle epithelium. Here, we show that a member of the BMP family, Gdf7, is required for normal seminal vesicle development…
64 Citations
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Collective knowledge that permeates the roles of TGF-β family members in the control of the ductal tissues in the vertebrate body is discussed.
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