The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth.

@article{Stottmann2001TheBA,
  title={The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth.},
  author={Rolf W Stottmann and Ryan M Anderson and John Klingensmith},
  journal={Developmental biology},
  year={2001},
  volume={240 2},
  pages={457-73}
}
Here we investigate the roles of the Bone Morphogenetic Protein (BMP) antagonists Chordin and Noggin in development of the mandible, which is derived from the first branchial arch (BA1). Both genes are expressed in the pharynx during early mandibular outgrowth and later in the mandibular process. Mice mutant for either Nog or Chd have only mild mandibular defects; however, pups of the genotype Chd(-/-);Nog(+/-) exhibit a range of mandibular truncation phenotypes, from normal to agnathia. A few… CONTINUE READING
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