The BMP antagonist noggin regulates cranial suture fusion

@article{Warren2003TheBA,
  title={The BMP antagonist noggin regulates cranial suture fusion},
  author={S. Warren and L. Brunet and R. Harland and A. Economides and M. Longaker},
  journal={Nature},
  year={2003},
  volume={422},
  pages={625-629}
}
During skull development, the cranial connective tissue framework undergoes intramembranous ossification to form skull bones (calvaria). As the calvarial bones advance to envelop the brain, fibrous sutures form between the calvarial plates. Expansion of the brain is coupled with calvarial growth through a series of tissue interactions within the cranial suture complex. Craniosynostosis, or premature cranial suture fusion, results in an abnormal skull shape, blindness and mental retardation… Expand
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