The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.

@article{Rahmani2009TheBP,
  title={The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways.},
  author={Mohamed Rahmani and Anh Anderson and Joseph Reza Habibi and Timothy Ryan Crabtree and Mandy Mayo and Hisashi Harada and Andrea Ferreira-Gonzalez and Paul C Dent and Steven Grant},
  journal={Blood},
  year={2009},
  volume={114 20},
  pages={4507-16}
}
Mechanisms underlying apoptosis induced by concomitant interruption of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 (MEK/ERK1/2) and phosphatidylinositol 3-kinase (PI3K)/Akt pathways were investigated in human leukemia cells. Inhibition of these pathways using the MEK inhibitor PD184352 or U0126 and the PI3K/Akt inhibitor perifosine strikingly induced apoptosis in multiple malignant human hematopoietic cells, and substantially reduced the colony-forming… CONTINUE READING

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