The BH3-only member Noxa causes apoptosis in melanoma cells by multiple pathways

Abstract

The molecular causes for resistance of melanoma to apoptosis are currently only partly understood. In the present study, we examined gene transfer and expression of the proapoptotic BH3-only protein Noxa as an alternative approach to chemotherapy and investigated the molecular mechanisms regulating Noxa-induced apoptosis. Noxa gene transfer caused… (More)
DOI: 10.1038/onc.2011.64

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