The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells.

@article{Zhong2012TheBM,
  title={The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells.},
  author={Jia-teng Zhong and Ye Xu and Hao-Wei Yi and Jing Su and Hui-mei Yu and Xi-yan Xiang and Xiao-ning Li and Zhi-chao Zhang and Lian-Kun Sun},
  journal={Cancer letters},
  year={2012},
  volume={323 2},
  pages={180-7}
}
Previous results showed that a novel BH3 mimetic S1 could induce cell death in a wide range of cancer types in vitro through Bax/Bak-dependent apoptosis. We demonstrated that in addition to mitochondrial pathway apoptosis, endoplasmic reticulum (ER) stress-associated apoptosis was also induced by S1. Moreover, S1 can induce autophagy in U251 cells, which may occur through ER stress and disruption of the association of Bcl-2 and Beclin 1. Inhibition of autophagy by the autophagic inhibitors 3… CONTINUE READING

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