The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.

@article{Hsu2017TheBP,
  title={The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries.},
  author={Sarah C Hsu and Thomas G Gilgenast and Caroline R Bartman and Christopher R. W. Edwards and Aaron J Stonestrom and Peng Huang and Daniel J Emerson and Perry Evans and Michael T Werner and Cheryl A. Keller and Belinda Giardine and Ross C. Hardison and Arjun Raj and Jennifer E Phillips-Cremins and Gerd A Blobel},
  journal={Molecular cell},
  year={2017},
  volume={66 1},
  pages={102-116.e7}
}
Bromodomain and extraterminal motif (BET) proteins are pharmacologic targets for the treatment of diverse diseases, yet the roles of individual BET family members remain unclear. We find that BRD2, but not BRD4, co-localizes with the architectural/insulator protein CCCTC-binding factor (CTCF) genome-wide. CTCF recruits BRD2 to co-bound sites whereas BRD2 is dispensable for CTCF occupancy. Disruption of a CTCF/BRD2-occupied element positioned between two unrelated genes enables regulatory… CONTINUE READING
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