The BEACH is hot: a LYST of emerging roles for BEACH-domain containing proteins in human disease.

@article{Cullinane2013TheBI,
  title={The BEACH is hot: a LYST of emerging roles for BEACH-domain containing proteins in human disease.},
  author={Andrew Robert Cullinane and Alejandro A. Sch{\"a}ffer and Marjan Huizing},
  journal={Traffic},
  year={2013},
  volume={14 7},
  pages={749-66}
}
BEACH (named after 'Beige and Chediak-Higashi') is a conserved ∼280 residue domain, present in nine human BEACH domain containing proteins (BDCPs). Most BDCPs are large, containing a PH-like domain for membrane association preceding their BEACH domain, and containing WD40 and other domains for ligand binding. Recent studies found that mutations in individual BDCPs cause several human diseases. BDCP alterations affect lysosome size (LYST and NSMAF), apoptosis (NSMAF), autophagy (LYST, WDFY3… CONTINUE READING
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