The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

@article{Egan2003TheBV,
  title={The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function},
  author={Michael Egan and Masami Kojima and Joseph H. Callicott and Terry E. Goldberg and Bhaskar S. Kolachana and Alessandro Bertolino and Eugene Zaitsev and Bert Gold and David Goldman and Michael Dean and Bai Lu and Daniel R. Weinberger},
  journal={Cell},
  year={2003},
  volume={112},
  pages={257-269}
}

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Brain-Derived Neurotrophic Factor val66met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance
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The results suggest that met carriers are able to recruit MTL activity to support successful memory processes, and reductions in cognitive performance observed in prior studies are not a ubiquitous effect associated with variants of the BDNF val66met genotype.
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The BDNF val-66-met Polymorphism Affects Neuronal Morphology and Synaptic Transmission in Cultured Hippocampal Neurons from Rett Syndrome Mice
TLDR
The results suggest that the val-BDNF variant contributes to RTT pathophysiology, and that BDNF-based therapies should take into consideration the BDNF genotype of the RTT individuals.
Impact of the BDNF Val66Met Polymorphism on Cognition
  • I. Dincheva, C. Glatt, F. Lee
  • Biology
    The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
  • 2012
TLDR
The authors generated a mouse model containing the BDNF Met allele, which they found to replicate the key phenotypes observed in humans and provided further insight into the functional impact of this SNP in vivo.
...
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