The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity.

@article{Bachmann2012TheBV,
  title={The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity.},
  author={V. Bachmann and Carina Klein and S. Bodenmann and N. Sch{\"a}fer and W. Berger and P. Brugger and H. Landolt},
  journal={Sleep},
  year={2012},
  volume={35 3},
  pages={
          335-44
        }
}
  • V. Bachmann, Carina Klein, +4 authors H. Landolt
  • Published 2012
  • Medicine, Psychology
  • Sleep
  • STUDY OBJECTIVES EEG slow waves are the hallmark of deep NREM sleep and may reflect the restorative functions of sleep. Evidence suggests that increased sleep slow waves after sleep deprivation reflect plastic synaptic processes, and that brain-derived neurotrophic factor (BDNF) is causally involved in their homeostatic regulation. The functional Val66Met polymorphism of the gene encoding pro-BDNF causes impaired activity-dependent secretion of mature BDNF protein. We investigated whether this… CONTINUE READING
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