The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity.

@article{Bachmann2012TheBV,
  title={The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity.},
  author={Val{\'e}rie Bachmann and Carina Klein and Sereina Lucia Bodenmann and N Foldvary Schaefer and Wolfgang H. Berger and Peter Brugger and Hans-Peter Landolt},
  journal={Sleep},
  year={2012},
  volume={35 3},
  pages={
          335-44
        }
}
STUDY OBJECTIVES EEG slow waves are the hallmark of deep NREM sleep and may reflect the restorative functions of sleep. Evidence suggests that increased sleep slow waves after sleep deprivation reflect plastic synaptic processes, and that brain-derived neurotrophic factor (BDNF) is causally involved in their homeostatic regulation. The functional Val66Met polymorphism of the gene encoding pro-BDNF causes impaired activity-dependent secretion of mature BDNF protein. We investigated whether this… CONTINUE READING

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