The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples.

Abstract

may either directly influence the binding of DISC1 and Citron proteins, or they may be markers of polymorphism(s) responsible for modulating binding. Alternately, we found the SNPs to have an association with BP in the study may reflect causal genetic variation in an adjacent gene. It is conceivable that Citron is one of a cluster of susceptibility genes for BP in the chromosomal region of 12q23–24. Together, our studies warrant further study of Citron and adjacent genes in larger samples and in other ethnic groups in the investigation of a possible etiology for major mood disorders.

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@article{Li2005TheBV, title={The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples.}, author={Y Li and Charles Rowland and Kristina M. Tacey and Joseph J. Catanese and J. Sninsky and John Hardy and Jason Powell and Simon Lovestone and John C. Morris and Leon Thal and Alison M. Goate and Michael J. Owen and James W. Williams and A Grupe}, journal={Molecular psychiatry}, year={2005}, volume={10 9}, pages={809-10} }