The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication.

@article{Wichers2008TheBV,
  title={The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication.},
  author={Marieke C Wichers and Gunter R L Kenis and Nele Jacobs and Ron Mengelers and Catherine A. Derom and Robert F M H Vlietinck and Jim van Os},
  journal={American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics},
  year={2008},
  volume={147B 1},
  pages={120-3}
}
Kaufman et al. [2006] reported a higher order interaction effect between specific genetic and environmental factors in a model of depressive symptoms, requiring independent replication. BDNF Val(66)Met and 5-HTTLPR genotypes were determined in female participants pertaining to a large ongoing twin study. Participants also filled in questionnaires on childhood adversity and depressive symptoms. Two- and three-way interactions between genetic polymorphisms and early adversity were examined in… CONTINUE READING

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Genetic susceptibility to family environment: BDNF Val66met and 5-HTTLPR influence depressive symptoms.

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