The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.

  title={The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.},
  author={Eric Santos Martin and Rossano Cesari and Francesca Pentimalli and Kristine E Yoder and Richard Fishel and Andrew L. Himelstein and Scott E. Martin and Andrew K. Godwin and Massimo Negrini and Carlo M. Croce},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 20},
Frequent allelic loss at human chromosome 11q23-q24 occurs in a wide variety of cancers, suggesting that this region may harbor a tumor suppressor gene. By constructing a physical map of the LOH11CR2 minimal region of loss on 11q23-q24 associated with lung and breast carcinomas, we were able to clone a hereditary translocation, t(11;12)(q23;q24), in a patient with early-onset breast cancer and family history of cancer. The breakpoint was found within 6 kb of the BCSC-1 candidate tumor… CONTINUE READING


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